Sleep apnea affects millions of Americans, causing fatigue, heart strain, and even memory issues. While CPAP machines and lifestyle changes help many, others struggle to find lasting relief. Fortunately, paid clinical trials for sleep apnea offer an opportunity to try new treatments while receiving expert medical care — and often getting compensated in the process.

If you’re wondering how to join one of these research studies, this guide walks you through everything you need to know — from eligibility and risks to where to find the highest-paying trials

What Are Sleep Apnea Clinical Trials?

Sleep apnea clinical trials are research studies that test new therapies, devices, or procedures for obstructive sleep apnea (OSA) and central sleep apnea. These studies are often funded by medical device companies, pharmaceutical firms, universities, or hospitals.

Some trials focus on:

• CPAP or alternative airway pressure devices
• Oral appliances
• New surgical techniques
• Nerve stimulation implants (like Inspire therapy)
• Drug-based therapies
• Weight loss treatments targeting sleep apnea

Many of these studies offer financial compensation for your time, often ranging from a few hundred to several thousand dollars.

Am I Eligible for a Trial?

Each clinical trial has specific eligibility criteria. Some common requirements include:

• A confirmed diagnosis of obstructive or central sleep apnea
• Certain levels of AHI (apnea-hypopnea index)
• Non-compliance with CPAP therapy
• Age within a certain range (typically 18–75)
• No serious medical conditions that could interfere with the study
• Not currently participating in another trial

Some trials seek people newly diagnosed with sleep apnea, while others target patients who’ve already tried (and failed) CPAP or other standard treatments.

What to Expect After Applying

If you find a trial you're interested in, here's what the process typically involves:

1. Pre-Screening Call

You’ll complete a phone or online screening to assess basic eligibility.

2. Informed Consent

If you're a match, you'll receive documents explaining the study, potential risks, and benefits.

3. Screening Visit

This may involve a sleep study (in-lab or at-home), physical exam, or diagnostic interviews.

4. Study Participation

You’ll follow the assigned treatment plan, which may include wearing a device, taking medication, or receiving a placebo.

5. Follow-Up and Compensation

You’ll return for follow-ups and receive payment as outlined—sometimes per visit, or in lump sums after certain milestones.

Tips for Getting Into High-Paying Studies

• Apply early. Trials often have limited spots.
• Be honest during screening. Misrepresenting your health history can disqualify you.
• Ask about payment structure. Know how and when you'll be paid.
• Look for trials that include overnight stays. These tend to pay more.
• Be flexible with scheduling. Some studies require multiple check-ins or follow-ups.